Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 737598..738291 Replicon chromosome
Accession NZ_CP116035
Organism Escherichia coli strain FAH

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag PGH49_RS03580 Protein ID WP_000415584.1
Coordinates 737598..737894 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PGH49_RS03585 Protein ID WP_000650107.1
Coordinates 737896..738291 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGH49_RS03545 (732686) 732686..733000 - 315 WP_000958598.1 putative quinol monooxygenase -
PGH49_RS03550 (733031) 733031..733612 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
PGH49_RS03555 (733931) 733931..734263 + 333 WP_000917685.1 DUF2645 family protein -
PGH49_RS03560 (734309) 734309..735658 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
PGH49_RS03565 (735655) 735655..736314 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
PGH49_RS03570 (736466) 736466..736858 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PGH49_RS03575 (736911) 736911..737393 + 483 WP_000183505.1 GyrI-like domain-containing protein -
PGH49_RS03580 (737598) 737598..737894 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
PGH49_RS03585 (737896) 737896..738291 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PGH49_RS03590 (738424) 738424..740031 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
PGH49_RS03595 (740169) 740169..742427 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T267643 WP_000415584.1 NZ_CP116035:737598-737894 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT267643 WP_000650107.1 NZ_CP116035:737896-738291 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References