Detailed information of TA system TA026764

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 1625608..1626196
• Replicon: chromosome
• Accession: NC_017372
• Organism: Helicobacter pylori India7 (Helicobacter pylori Ind7)

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: T5CGR9
• Locus tag: HPIN_RS07790
• Protein ID: WP_000921933.1
• Coordinates: 1625915..1626196 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: T5DIX9
• Locus tag: HPIN_RS07785
• Protein ID: WP_000065296.1
• Coordinates: 1625608..1625922 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPIN_RS07760	1620959..1621627	-	669	Protein_1484	P-type conjugative transfer protein TrbL	-
HPIN_RS07765	1621624..1621797	+	174	Protein_1485	ParA family protein	-
HPIN_RS07770	1621879..1622163	+	285	WP_000394635.1	hypothetical protein	-
HPIN_RS07775	1622247..1623380	+	1134	WP_049768375.1	hypothetical protein	-
HPIN_RS07780	1623405..1625314	-	1910	Protein_1488	relaxase/mobilization nuclease domain-containing protein	-
HPIN_RS07785	1625608..1625922	+	315	WP_000065296.1	hypothetical protein	Antitoxin
HPIN_RS07790	1625915..1626196	+	282	WP_000921933.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPIN_RS07795	1626447..1627022	-	576	WP_001146911.1	hypothetical protein	-
HPIN_RS07800	1627080..1628147	-	1068	WP_000014381.1	elongation factor Ts	-
HPIN_RS07805	1628147..1628941	-	795	WP_000258279.1	30S ribosomal protein S2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	fliI / fliQ	1587161..1646044	58883

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10875.80 Da
• Isoelectric Point: 9.5726

>T26764 WP_000921933.1 NC_017372:1625915-1626196 [Helicobacter pylori India7]
MLKVRTKKDFLKDFNKHILSGRITESDVASIVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T26764 NC_017372:1625915-1626196 [Helicobacter pylori India7]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCTGGGCGTATTACAGAAAGCGA
TGTTGCAAGCATTGTTGATTGTCTCAAAGAGCAAAAACCACTCCAACAAAAATATTGCGACCATGCCTTGAGTGGCAATC
TTAAAGGGCTGAGAGAATGCCATGTTAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12137.57 Da
• Isoelectric Point: 5.2066

>AT26764 WP_000065296.1 NC_017372:1625608-1625922 [Helicobacter pylori India7]
MSNIITDYSQYNEKQLHNFLNSIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Nucleotide

• Length: 315 bp

>AT26764 NC_017372:1625608-1625922 [Helicobacter pylori India7]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACTCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAGGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAATACGATCGCCTCAAAAGATGACCCAGAG
TGCGATGTTTCGTTTGGAGACTTTAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Structures

Toxin

• AlphaFold DB: T5CGR9

Antitoxin

• AlphaFold DB: T5DIX9