Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1531363..1531954 Replicon chromosome
Accession NZ_CP116005
Organism Sphingosinicella microcystinivorans strain DMF-3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PE061_RS07510 Protein ID WP_271258478.1
Coordinates 1531679..1531954 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PE061_RS07505 Protein ID WP_271258477.1
Coordinates 1531363..1531659 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PE061_RS07480 (PE061_07480) 1527013..1528230 - 1218 WP_271258472.1 acyl-CoA dehydrogenase family protein -
PE061_RS07485 (PE061_07485) 1528243..1529337 - 1095 WP_271258473.1 acyl-CoA dehydrogenase family protein -
PE061_RS07490 (PE061_07490) 1529414..1529611 - 198 WP_271258474.1 DUF1192 domain-containing protein -
PE061_RS07495 (PE061_07495) 1529688..1530710 + 1023 WP_271258475.1 NAD(P)H-quinone oxidoreductase -
PE061_RS07500 (PE061_07500) 1530688..1531308 + 621 WP_271258476.1 glutathione S-transferase family protein -
PE061_RS07505 (PE061_07505) 1531363..1531659 - 297 WP_271258477.1 HigA family addiction module antitoxin Antitoxin
PE061_RS07510 (PE061_07510) 1531679..1531954 - 276 WP_271258478.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PE061_RS07515 (PE061_07515) 1532160..1533011 + 852 WP_271259151.1 UDP-2,3-diacylglucosamine diphosphatase -
PE061_RS07520 (PE061_07520) 1533061..1534080 + 1020 WP_271258479.1 glycosyltransferase family 1 protein -
PE061_RS07525 (PE061_07525) 1534186..1534812 + 627 WP_271259152.1 DUF1013 domain-containing protein -
PE061_RS07530 (PE061_07530) 1534864..1535982 + 1119 WP_271258480.1 MBL fold metallo-hydrolase -
PE061_RS07535 (PE061_07535) 1535972..1536658 + 687 WP_271258481.1 HAD-IA family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-91)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-95)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10301.57 Da        Isoelectric Point: 8.4495

>T267608 WP_271258478.1 NZ_CP116005:c1531954-1531679 [Sphingosinicella microcystinivorans]
MIRSYRSKPLRRFAEEGNASKLPVANTDRVRRILAALEAAVTPEEMNLPGYRFHGLQGKPRRYAVDASGNYRITFGFDGT
DAVDVDIEDYH

Download         Length: 276 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10555.35 Da        Isoelectric Point: 7.2029

>AT267608 WP_271258477.1 NZ_CP116005:c1531659-1531363 [Sphingosinicella microcystinivorans]
MPMKGLRPTHPGEILREDVLPALGKSKTEIASLLGISRPTLYDILGERQPITPHTALRLGKLLGNGGGFWLRMQAAYDLA
VEGEAIAAEIERIPTLAA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References