267583

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2491410..2491642 Replicon chromosome
Accession NZ_CP115992
Organism Enterococcus faecalis strain ESC1

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag PE069_RS12030 Protein ID WP_002355568.1
Coordinates 2491410..2491526 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2491437..2491642 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PE069_RS12020 (2486848) 2486848..2489106 + 2259 WP_002363179.1 DNA helicase PcrA -
PE069_RS12025 (2489232) 2489232..2491262 + 2031 WP_010828568.1 NAD-dependent DNA ligase LigA -
PE069_RS12030 (2491410) 2491410..2491526 + 117 WP_002355568.1 putative holin-like toxin Toxin
- (2491437) 2491437..2491642 - 206 NuclAT_3 - Antitoxin
PE069_RS12035 (2491844) 2491844..2492149 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
PE069_RS12040 (2492149) 2492149..2493618 + 1470 WP_002368026.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
PE069_RS12045 (2493618) 2493618..2495048 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
PE069_RS12050 (2495067) 2495067..2496155 + 1089 WP_002383001.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T267583 WP_002355568.1 NZ_CP115992:2491410-2491526 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT267583 NZ_CP115992:c2491642-2491437 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATGC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References