Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 301112..301700 Replicon chromosome
Accession NC_017367
Organism Helicobacter pylori F57

Toxin (Protein)


Gene name TfiT Uniprot ID M3P300
Locus tag HPF57_RS01500 Protein ID WP_000921941.1
Coordinates 301112..301393 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID E6NQF6
Locus tag HPF57_RS01505 Protein ID WP_000065312.1
Coordinates 301386..301700 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPF57_RS01465 296283..296546 + 264 WP_000564642.1 hypothetical protein -
HPF57_RS08290 296543..296695 + 153 WP_014535548.1 hypothetical protein -
HPF57_RS01475 296841..297782 + 942 WP_000625136.1 Flp pilus assembly complex ATPase component TadA -
HPF57_RS01480 297779..298234 + 456 WP_000795411.1 hypothetical protein -
HPF57_RS01485 298231..298521 + 291 WP_000159829.1 hypothetical protein -
HPF57_RS01490 298522..299079 + 558 WP_001167763.1 hypothetical protein -
HPF57_RS01495 299080..300803 + 1724 Protein_285 type IV secretory system conjugative DNA transfer family protein -
HPF57_RS01500 301112..301393 - 282 WP_000921941.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPF57_RS01505 301386..301700 - 315 WP_000065312.1 hypothetical protein Antitoxin
HPF57_RS01510 301996..303906 + 1911 WP_001162750.1 relaxase/mobilization nuclease domain-containing protein -
HPF57_RS01515 303931..305094 - 1164 WP_000753629.1 hypothetical protein -
HPF57_RS01520 305126..305395 - 270 WP_000394631.1 hypothetical protein -
HPF57_RS01525 305477..306133 - 657 WP_000587366.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - HP0256 277195..328268 51073


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10891.80 Da        Isoelectric Point: 9.5726

>T26758 WP_000921941.1 NC_017367:c301393-301112 [Helicobacter pylori F57]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T26758 NC_017367:c301393-301112 [Helicobacter pylori F57]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTACAGAAAGCGA
TGTTACAAGCGTTGTTGATTGTCTCAAAGAGCAAAAACCGCTCCAACAAAAGTATTGCGACCATGCCTTAAGTGGCAATC
TTAAAGGGTTGAGAGAGTGTCATGTTAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAGCAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12186.65 Da        Isoelectric Point: 4.9309

>AT26758 WP_000065312.1 NC_017367:c301700-301386 [Helicobacter pylori F57]
MSNIITDYSQYNEKQLYNLLNAIEKQWLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT26758 NC_017367:c301700-301386 [Helicobacter pylori F57]
ATGTCAAATATTATTACAGATTATTCGCAATACAATGAAAAGCAACTGTACAATTTATTAAACGCCATTGAAAAACAATG
GCTTAAGGCAGAAGGGGATAAAAACAAGGCAATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTCTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGCTAAATACGATCGCCTCAAAAGATGACCCAGAA
TGCGATGTTTCGTTTGGAGATTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M3P300

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q2QNU5

References