Detailed information of TA system TA267575

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1891698..1891997
• Replicon: chromosome
• Accession: NZ_CP115992
• Organism: Enterococcus faecalis strain ESC1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PE069_RS09055
• Protein ID: WP_271232318.1
• Coordinates: 1891698..1891880 (+)
• Length: 61 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1891813..1891997 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PE069_RS09040 (1887485)	1887485..1888084	-	600	WP_225560887.1	RloB family protein	-
PE069_RS09045 (1888093)	1888093..1889388	-	1296	WP_192177102.1	ATP-binding protein	-
PE069_RS09050 (1889850)	1889850..1891466	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
PE069_RS09055 (1891698)	1891698..1891880	+	183	WP_271232318.1	type I toxin-antitoxin system toxin PepG1	Toxin
- (1891813)	1891813..1891997	-	185	NuclAT_9	-	Antitoxin
- (1891854)	1891854..1891997	-	144	NuclAT_12	-	-
PE069_RS09060 (1891999)	1891999..1892139	+	141	WP_116593266.1	putative holin-like toxin	-
- (1892072)	1892072..1892331	-	260	NuclAT_8	-	-
- (1892283)	1892283..1892332	+	50	NuclAT_14	-	-
- (1892113)	1892113..1892333	-	221	NuclAT_11	-	-
PE069_RS09065 (1892334)	1892334..1895333	-	3000	WP_271232319.1	WxL domain-containing protein	-
PE069_RS09070 (1895314)	1895314..1895682	-	369	WP_096398072.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (27-60)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6996.46 Da
• Isoelectric Point: 10.8172

>T267575 WP_271232318.1 NZ_CP115992:1891698-1891880 [Enterococcus faecalis]
MAVAIQSEREVMRMHVFPKFRERRGLLSAYETIQTILGFGMFTIDLIALIVKLLKNDKKK

Nucleotide

• Length: 183 bp

Antitoxin

Nucleotide

• Length: 185 bp

>AT267575 NZ_CP115992:c1891997-1891813 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAATCAATGGTAAACATACCAA

Structures

Antitoxin