Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-RNAII/-
Location 1819480..1819738 Replicon chromosome
Accession NZ_CP115992
Organism Enterococcus faecalis strain ESC1

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag PE069_RS08725 Protein ID WP_002392696.1
Coordinates 1819595..1819738 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name RNAII
Locus tag -
Coordinates 1819480..1819662 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PE069_RS08710 (1815041) 1815041..1815754 - 714 WP_002367455.1 trehalose operon repressor -
PE069_RS08715 (1816016) 1816016..1818760 + 2745 WP_271232302.1 glycosyl hydrolase family 65 protein -
PE069_RS08720 (1818775) 1818775..1819425 + 651 WP_033597602.1 beta-phosphoglucomutase -
- (1819494) 1819494..1819621 + 128 NuclAT_13 - -
- (1819480) 1819480..1819662 + 183 NuclAT_10 - Antitoxin
PE069_RS08725 (1819595) 1819595..1819738 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
PE069_RS08730 (1819969) 1819969..1820940 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
PE069_RS08735 (1821115) 1821115..1821552 - 438 WP_271232303.1 peptide-methionine (R)-S-oxide reductase MsrB -
PE069_RS08740 (1821685) 1821685..1822239 - 555 WP_002354869.1 Maf family protein -
PE069_RS08745 (1822264) 1822264..1824396 - 2133 WP_057086606.1 DNA mismatch repair endonuclease MutL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T267572 WP_002392696.1 NZ_CP115992:c1819738-1819595 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 183 bp

>AT267572 NZ_CP115992:1819480-1819662 [Enterococcus faecalis]
TGCTAGAATGTAGATGAAAAGAGAGCTGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACTTTTTGAAT
TATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGTGCAAT
CAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References