Detailed information of TA system TA267565

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1756639..1756899
• Replicon: chromosome
• Accession: NZ_CP115992
• Organism: Enterococcus faecalis strain ESC1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PE069_RS08435
• Protein ID: WP_021164442.1
• Coordinates: 1756798..1756899 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1756639..1756844 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PE069_RS08410 (1752293)	1752293..1753246	-	954	WP_271232295.1	siderophore ABC transporter substrate-binding protein	-
PE069_RS08415 (1753285)	1753285..1754040	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
PE069_RS08420 (1754037)	1754037..1755002	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
PE069_RS08425 (1754999)	1754999..1755946	-	948	WP_002368428.1	iron chelate uptake ABC transporter family permease subunit	-
PE069_RS08430 (1756131)	1756131..1756583	+	453	WP_002359057.1	YueI family protein	-
- (1756639)	1756639..1756844	+	206	NuclAT_7	-	Antitoxin
- (1756676)	1756676..1756861	+	186	NuclAT_5	-	-
PE069_RS08435 (1756798)	1756798..1756899	-	102	WP_021164442.1	putative holin-like toxin	Toxin
- (1757074)	1757074..1757283	+	210	NuclAT_6	-	-
- (1757108)	1757108..1757287	+	180	NuclAT_4	-	-
PE069_RS08440 (1757232)	1757232..1757333	-	102	WP_075551663.1	putative holin-like toxin	-
PE069_RS08445 (1757522)	1757522..1759792	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
PE069_RS08450 (1759963)	1759963..1760463	+	501	WP_002354954.1	cysteine hydrolase family protein	-
PE069_RS08455 (1760809)	1760809..1761705	+	897	WP_002365354.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3625.38 Da
• Isoelectric Point: 4.5869

>T267565 WP_021164442.1 NZ_CP115992:c1756899-1756798 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 206 bp

>AT267565 NZ_CP115992:1756639-1756844 [Enterococcus faecalis]
TTCCATTTATAATAGAATTGTGCTATTATAAAGATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTATACCAACG
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGT
TATTTTTTATCATTTTTCGTTGCTTCAAGGATACCGAAAATCAGTA

Structures

Antitoxin