Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 956537..957125 Replicon chromosome
Accession NC_017361
Organism Helicobacter pylori SouthAfrica7 (Helicobacter pylori SAfr7)

Toxin (Protein)


Gene name TfiT Uniprot ID E8QSE9
Locus tag HPSA_RS04485 Protein ID WP_000921940.1
Coordinates 956844..957125 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID E8QSE8
Locus tag HPSA_RS04480 Protein ID WP_000065294.1
Coordinates 956537..956851 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPSA_RS04460 951974..952630 + 657 WP_000587419.1 ParA family protein -
HPSA_RS04465 952709..952993 + 285 WP_000394624.1 hypothetical protein -
HPSA_RS04470 953020..954192 + 1173 WP_000753651.1 hypothetical protein -
HPSA_RS04475 954212..956122 - 1911 WP_001162746.1 relaxase/mobilization nuclease domain-containing protein -
HPSA_RS04480 956537..956851 + 315 WP_000065294.1 hypothetical protein Antitoxin
HPSA_RS04485 956844..957125 + 282 WP_000921940.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPSA_RS04490 957262..959007 - 1746 WP_001208188.1 type IV secretory system conjugative DNA transfer family protein -
HPSA_RS04495 959008..959565 - 558 WP_001167790.1 hypothetical protein -
HPSA_RS04500 959566..959856 - 291 WP_000159816.1 hypothetical protein -
HPSA_RS04505 959853..960308 - 456 WP_000753653.1 hypothetical protein -
HPSA_RS04510 960305..961246 - 942 WP_000625138.1 Flp pilus assembly complex ATPase component TadA -
HPSA_RS04515 961246..961545 - 300 WP_000660142.1 hypothetical protein -
HPSA_RS04520 961542..961805 - 264 WP_000578846.1 hypothetical protein -
HPSA_RS04525 961795..962091 - 297 WP_000422438.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10933.84 Da        Isoelectric Point: 9.5912

>T26754 WP_000921940.1 NC_017361:956844-957125 [Helicobacter pylori SouthAfrica7]
MLKVRTKKDFLKDFNKHILSGRITESDVTSIVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKR

Download         Length: 282 bp

>T26754 NC_017361:956844-957125 [Helicobacter pylori SouthAfrica7]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCTGGGCGTATTACAGAAAGCGA
TGTTACAAGCATTGTTGATTGCCTTAAAGAACAAAAACCACTCCAACAAAAATATTGCGACCATGCTTTGAGCGGTAATC
TTAAAGGGTTGAGAGAATGCCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAGGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12166.60 Da        Isoelectric Point: 5.2068

>AT26754 WP_000065294.1 NC_017361:956537-956851 [Helicobacter pylori SouthAfrica7]
MSNIITDYSQYNEKQLHNFLNSIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTPSLLNTIASKDDPE
YDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT26754 NC_017361:956537-956851 [Helicobacter pylori SouthAfrica7]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACTCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACCAAGTTTGTTAAATACGATCGCTTCAAAAGATGACCCAGAA
TACGATGTTTCGTTTGGAGACTTCAATGATTTTTTGCAAATAGCGAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E8QSE9

Antitoxin

Source ID Structure
AlphaFold DB A0A2T6R0U3

References