Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 105435..106072 Replicon plasmid pmega
Accession NZ_CP115953
Organism Ralstonia solanacearum CFBP2957

Toxin (Protein)


Gene name higB Uniprot ID D8P759
Locus tag PG903_RS16640 Protein ID WP_013207463.1
Coordinates 105435..105764 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PG903_RS16645 Protein ID WP_176462254.1
Coordinates 105761..106072 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG903_RS16625 101140..102303 - 1164 WP_013207460.1 2-methylcitrate synthase -
PG903_RS16630 102342..103238 - 897 WP_013207461.1 methylisocitrate lyase -
PG903_RS16635 103432..105384 + 1953 WP_013207462.1 propionate catabolism operon regulatory protein PrpR -
PG903_RS16640 105435..105764 + 330 WP_013207463.1 hypothetical protein Toxin
PG903_RS16645 105761..106072 + 312 WP_176462254.1 transcriptional regulator Antitoxin
PG903_RS16650 106304..106612 - 309 WP_176462255.1 type II toxin-antitoxin system YafQ family toxin -
PG903_RS16655 106557..106853 - 297 WP_013207466.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
PG903_RS16660 107455..108288 - 834 WP_176462402.1 DUF2242 domain-containing protein -
PG903_RS16665 108570..108941 + 372 WP_013207469.1 hypothetical protein -
PG903_RS16670 109134..109874 - 741 WP_013207470.1 metallophosphoesterase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / cyaB / flgG / fliM / fliI / acrB / adeG / cheY / cheB / cheW / motA 1..2210741 2210741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-91)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12425.94 Da        Isoelectric Point: 5.2566

>T267536 WP_013207463.1 NZ_CP115953:105435-105764 [Ralstonia solanacearum CFBP2957]
MDATPIELPGEHDLSDDEYSALQQELLAQPDAGDVIKGTGGLRKLRFSDKRRGKGKRGGLRVIYYHWDGGSQFWMFVVYD
KDEAIDLSSDERKVLARLLEQEVKARSER

Download         Length: 330 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11636.59 Da        Isoelectric Point: 10.3969

>AT267536 WP_176462254.1 NZ_CP115953:105761-106072 [Ralstonia solanacearum CFBP2957]
MKRNLFSELKEGMDALAAEREGKMTLRKVEVRVLQPIDVTAEEIKAVRAAAHASQAVMARRLRVNVRTYQNWEQGTAKPN
TQAAVLIKLVEKHPETLQMLEAL

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D8P759

Antitoxin

Source ID Structure

References