Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 110719..111356 Replicon plasmid pmega
Accession NZ_CP115947
Organism Ralstonia solanacearum MolK2

Toxin (Protein)


Gene name higB Uniprot ID A0A1C0UHE0
Locus tag PG909_RS14115 Protein ID WP_003262800.1
Coordinates 110719..111048 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PG909_RS14120 Protein ID WP_003274539.1
Coordinates 111045..111356 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG909_RS14100 106428..107591 - 1164 WP_197336754.1 2-methylcitrate synthase -
PG909_RS14105 107629..108525 - 897 WP_003274537.1 methylisocitrate lyase -
PG909_RS14110 108719..110668 + 1950 WP_003274538.1 propionate catabolism operon regulatory protein PrpR -
PG909_RS14115 110719..111048 + 330 WP_003262800.1 hypothetical protein Toxin
PG909_RS14120 111045..111356 + 312 WP_003274539.1 transcriptional regulator Antitoxin
PG909_RS14125 111507..111815 - 309 WP_003262797.1 type II toxin-antitoxin system YafQ family toxin -
PG909_RS14130 111760..112071 - 312 WP_003262795.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
PG909_RS14135 112658..113491 - 834 WP_042551581.1 DUF2242 domain-containing protein -
PG909_RS14140 113689..114006 + 318 Protein_96 IS5/IS1182 family transposase -
PG909_RS14145 114540..114761 + 222 WP_080895126.1 hypothetical protein -
PG909_RS14150 114901..115311 - 411 WP_042550962.1 hypothetical protein -
PG909_RS14155 115319..116059 - 741 WP_003274543.1 metallophosphoesterase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / icl 1..2326525 2326525


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-91)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12457.90 Da        Isoelectric Point: 4.9855

>T267530 WP_003262800.1 NZ_CP115947:110719-111048 [Ralstonia solanacearum MolK2]
MDATPIELPGEHDLSDDEYSALQQELLAQPDAGDVIKGTGGLRKLRFSDKRRGKGKRGGLRVIYYHWDGSSQFWMFVVYD
KDEADDLSSDERKVLARLLEQEVKARSER

Download         Length: 330 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11650.61 Da        Isoelectric Point: 10.3969

>AT267530 WP_003274539.1 NZ_CP115947:111045-111356 [Ralstonia solanacearum MolK2]
MKRNLFAELKEGMDALTAEREGKMTLRKVEVRVLQPIDVTAEEIKAVRAAAHASQAVMARRLRVNVRTYQNWEQGTAKPN
TQAAVLIKLVEKHPETLQMLEAL

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C0UHE0

Antitoxin

Source ID Structure

References