Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 104837..105489 Replicon plasmid pmega
Accession NZ_CP115945
Organism Ralstonia syzygii R24

Toxin (Protein)


Gene name higB Uniprot ID G3AAL2
Locus tag PG906_RS18220 Protein ID WP_075465943.1
Coordinates 104837..105181 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PG906_RS18225 Protein ID WP_197334098.1
Coordinates 105178..105489 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG906_RS18205 100560..101723 - 1164 WP_197333672.1 2-methylcitrate synthase -
PG906_RS18210 101758..102654 - 897 WP_197334100.1 methylisocitrate lyase -
PG906_RS18215 102849..104786 + 1938 WP_197334099.1 propionate catabolism operon regulatory protein PrpR -
PG906_RS18220 104837..105181 + 345 WP_075465943.1 toxin Toxin
PG906_RS18225 105178..105489 + 312 WP_197334098.1 transcriptional regulator Antitoxin
PG906_RS18230 105628..106455 - 828 WP_197334097.1 DUF2242 domain-containing protein -
PG906_RS18235 106760..107314 + 555 WP_197334096.1 hypothetical protein -
PG906_RS18240 107555..108295 - 741 WP_197334095.1 metallophosphoesterase family protein -
PG906_RS18245 108566..110383 + 1818 WP_231649772.1 3'-5' exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / cyaB / flgC / flgG / fliM / fliG / fliI / adeG / cheY / cheB / cheW / motA 1..1751279 1751279


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13434.09 Da        Isoelectric Point: 5.9519

>T267524 WP_075465943.1 NZ_CP115945:104837-105181 [Ralstonia syzygii R24]
MDATFIELPPFQRLREHYLSDDEYRALQQELLAQPDAGDVIRGTSGLRKLRFSDKRRGKGKRGGLRVIYYYWDEGGQFWM
FAVYDKDEADDLSSDERKVLARLLEQEVKARSER

Download         Length: 345 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11605.62 Da        Isoelectric Point: 10.7132

>AT267524 WP_197334098.1 NZ_CP115945:105178-105489 [Ralstonia syzygii R24]
MKRNLFAELKEGMDALAAEREGKTTLRKVKVRVLQPVDVTAEEIKAVRAAAHASQAVMARRLRVNVRTYQNWEQGTAKPN
TQAAVLIKLVEKHPEMLQMLEAL

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3AAL2

Antitoxin

Source ID Structure

References