Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 219047..219683 Replicon plasmid pAtK224a
Accession NZ_CP115926
Organism Agrobacterium fabacearum strain K224

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag G6L41_RS23840 Protein ID WP_173994831.1
Coordinates 219047..219328 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag G6L41_RS23845 Protein ID WP_025594268.1
Coordinates 219384..219683 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6L41_RS23815 (G6L41_023815) 214629..214907 + 279 WP_149916628.1 helix-turn-helix transcriptional regulator -
G6L41_RS23820 (G6L41_023820) 214911..215194 + 284 Protein_203 restriction endonuclease subunit R -
G6L41_RS23825 (G6L41_023825) 216320..217240 - 921 WP_173994833.1 LysR family transcriptional regulator -
G6L41_RS23830 (G6L41_023830) 217484..218398 + 915 WP_173994832.1 nucleotidyltransferase and HEPN domain-containing protein -
G6L41_RS23835 (G6L41_023835) 218482..218882 - 401 Protein_206 M15 family metallopeptidase -
G6L41_RS23840 (G6L41_023840) 219047..219328 + 282 WP_173994831.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6L41_RS23845 (G6L41_023845) 219384..219683 + 300 WP_025594268.1 HigA family addiction module antitoxin Antitoxin
G6L41_RS23850 (G6L41_023850) 220027..220272 - 246 WP_173994830.1 hypothetical protein -
G6L41_RS23855 (G6L41_023855) 220373..221269 - 897 WP_236762325.1 contractile injection system protein, VgrG/Pvc8 family -
G6L41_RS23860 (G6L41_023860) 221380..222090 - 711 WP_173994829.1 autoinducer binding domain-containing protein -
G6L41_RS23865 (G6L41_023865) 222087..222851 - 765 WP_173994828.1 acyl-homoserine-lactone synthase -
G6L41_RS23870 (G6L41_023870) 223008..223727 - 720 WP_173994827.1 LuxR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..485342 485342


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-97)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10641.05 Da        Isoelectric Point: 8.0459

>T267494 WP_173994831.1 NZ_CP115926:219047-219328 [Agrobacterium fabacearum]
MIRSFKNRLTSSIDDGSVKKGFPADLVRRAQQLLTILDAATTVEDLRSPPGNRLEKLFGDREGQHSIRINKQWRICFVWT
EAGPDNVEITDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11052.93 Da        Isoelectric Point: 6.4689

>AT267494 WP_025594268.1 NZ_CP115926:219384-219683 [Agrobacterium fabacearum]
MTITKSPAIHPGEILRELYLEPLDMSAYALAKHLNIPRTRIERIVAEKLGITADTALRLAKFFKTTPEYWLNLQNAFDIK
SAAAMLEADLAAIKELEAA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References