26749

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 244607..245195 Replicon chromosome
Accession NC_017358
Organism Helicobacter pylori Cuz20

Toxin (Protein)


Gene name TfiT Uniprot ID M3P300
Locus tag HPCU_RS01245 Protein ID WP_000921941.1
Coordinates 244607..244888 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID A0A0E0WAZ1
Locus tag HPCU_RS01250 Protein ID WP_000065288.1
Coordinates 244881..245195 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPCU_RS01210 239807..240070 + 264 WP_000564645.1 hypothetical protein -
HPCU_RS01215 240067..240365 + 299 Protein_231 hypothetical protein -
HPCU_RS01220 240365..241306 + 942 WP_000625128.1 Flp pilus assembly complex ATPase component TadA -
HPCU_RS01225 241303..241731 + 429 WP_014534191.1 hypothetical protein -
HPCU_RS01230 241756..242046 + 291 WP_000159820.1 hypothetical protein -
HPCU_RS01235 242047..242604 + 558 WP_001167784.1 hypothetical protein -
HPCU_RS01240 242605..244332 + 1728 WP_001208200.1 type IV secretory system conjugative DNA transfer family protein -
HPCU_RS01245 244607..244888 - 282 WP_000921941.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPCU_RS01250 244881..245195 - 315 WP_000065288.1 hypothetical protein Antitoxin
HPCU_RS01255 245476..247383 + 1908 WP_001162708.1 relaxase/mobilization nuclease domain-containing protein -
HPCU_RS01260 247408..248592 - 1185 WP_000665504.1 hypothetical protein -
HPCU_RS01265 248624..248893 - 270 WP_000394629.1 hypothetical protein -
HPCU_RS01270 248978..249634 - 657 WP_000587367.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - futC1 / futC2 / tlpA / tlpB / flaB / rfaJ / fliR / rfaJ 85055..258147 173092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10891.80 Da        Isoelectric Point: 9.5726

>T26749 WP_000921941.1 NC_017358:c244888-244607 [Helicobacter pylori Cuz20]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T26749 NC_017358:c244888-244607 [Helicobacter pylori Cuz20]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTACAGAAAGCGA
TGTTACAAGCGTTGTTGATTGCCTCAAAGAGCAAAAACCACTCCAACAAAAGTATTGCGACCATGCCTTGAGCGGCAATC
TTAAAGGACTGAGAGAATGCCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12139.64 Da        Isoelectric Point: 5.7560

>AT26749 WP_000065288.1 NC_017358:c245195-244881 [Helicobacter pylori Cuz20]
MSNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDNPE
CDVSFGDFNDFLQIAKQERERRNA

Download         Length: 315 bp

>AT26749 NC_017358:c245195-244881 [Helicobacter pylori Cuz20]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACGCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAATACGATCGCCTCAAAAGATAACCCAGAA
TGCGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCGTAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M3P300

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0WAZ1

References