Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2546328..2546851 Replicon chromosome
Accession NZ_CP115887
Organism Staphylococcus aureus strain C308

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag PCM89_RS12720 Protein ID WP_000074048.1
Coordinates 2546328..2546594 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag PCM89_RS12725 Protein ID WP_000587616.1
Coordinates 2546594..2546851 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCM89_RS12700 (2541539) 2541539..2542726 - 1188 WP_000026196.1 MFS transporter -
PCM89_RS12705 (2543120) 2543120..2543896 - 777 WP_000072155.1 iron export ABC transporter permease subunit FetB -
PCM89_RS12710 (2543889) 2543889..2544551 - 663 WP_000923509.1 ATP-binding cassette domain-containing protein -
PCM89_RS12715 (2544897) 2544897..2545973 - 1077 WP_001076688.1 M42 family metallopeptidase -
PCM89_RS12720 (2546328) 2546328..2546594 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
PCM89_RS12725 (2546594) 2546594..2546851 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PCM89_RS12730 (2547210) 2547210..2547665 + 456 WP_000732088.1 DUF1307 domain-containing protein -
PCM89_RS12735 (2547833) 2547833..2549410 - 1578 WP_000143486.1 FMN-binding glutamate synthase family protein -
PCM89_RS12740 (2549605) 2549605..2550354 + 750 WP_000072439.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T267473 WP_000074048.1 NZ_CP115887:c2546594-2546328 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT267473 WP_000587616.1 NZ_CP115887:c2546851-2546594 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References