Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2488321..2488838 Replicon chromosome
Accession NZ_CP115887
Organism Staphylococcus aureus strain C308

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag PCM89_RS12440 Protein ID WP_000113261.1
Coordinates 2488321..2488587 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag PCM89_RS12445 Protein ID WP_000584499.1
Coordinates 2488587..2488838 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCM89_RS12410 (2483758) 2483758..2484294 - 537 WP_000169319.1 GNAT family N-acetyltransferase -
PCM89_RS12415 (2484528) 2484528..2485352 - 825 WP_000594637.1 formate/nitrite transporter family protein -
PCM89_RS12420 (2485555) 2485555..2485737 - 183 WP_000250735.1 hypothetical protein -
PCM89_RS12425 (2485824) 2485824..2486291 - 468 WP_000153345.1 SRPBCC domain-containing protein -
PCM89_RS12430 (2486477) 2486477..2488027 - 1551 WP_000727760.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
PCM89_RS12435 (2488215) 2488215..2488286 - 72 WP_223200558.1 hypothetical protein -
PCM89_RS12440 (2488321) 2488321..2488587 - 267 WP_000113261.1 Txe/YoeB family addiction module toxin Toxin
PCM89_RS12445 (2488587) 2488587..2488838 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PCM89_RS12450 (2489001) 2489001..2489102 - 102 Protein_2410 hypothetical protein -
PCM89_RS12455 (2489109) 2489109..2489708 - 600 WP_000162810.1 DsbA family protein -
PCM89_RS12460 (2489727) 2489727..2490089 - 363 WP_000819843.1 DUF4467 domain-containing protein -
PCM89_RS12465 (2490344) 2490344..2491594 + 1251 WP_001012231.1 FemA/FemB family glycyltransferase FmhA -
PCM89_RS12470 (2491679) 2491679..2492410 - 732 WP_000615455.1 amino acid ABC transporter ATP-binding protein -
PCM89_RS12475 (2492407) 2492407..2493126 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10452.02 Da        Isoelectric Point: 10.0373

>T267471 WP_000113261.1 NZ_CP115887:c2488587-2488321 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDKHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT267471 WP_000584499.1 NZ_CP115887:c2488838-2488587 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References