Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF2/-
Location 2050055..2050354 Replicon chromosome
Accession NZ_CP115887
Organism Staphylococcus aureus strain C308

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag PCM89_RS10060 Protein ID WP_011447039.1
Coordinates 2050178..2050354 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2050055..2050110 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCM89_RS10020 2045386..2045646 + 261 WP_001791826.1 hypothetical protein -
PCM89_RS10025 2045699..2046049 - 351 WP_000702263.1 complement inhibitor SCIN-A -
PCM89_RS10030 2046734..2047183 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
PCM89_RS10035 2047278..2047613 - 336 Protein_1941 SH3 domain-containing protein -
PCM89_RS10040 2048263..2048754 - 492 WP_000919349.1 staphylokinase -
PCM89_RS10045 2048945..2049700 - 756 WP_000861039.1 CHAP domain-containing protein -
PCM89_RS10050 2049712..2049966 - 255 WP_000611512.1 phage holin -
PCM89_RS10055 2050018..2050125 + 108 WP_001791821.1 hypothetical protein -
- 2050047..2050186 + 140 NuclAT_1 - -
- 2050047..2050186 + 140 NuclAT_1 - -
- 2050047..2050186 + 140 NuclAT_1 - -
- 2050047..2050186 + 140 NuclAT_1 - -
- 2050055..2050110 + 56 - - Antitoxin
PCM89_RS10060 2050178..2050354 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
PCM89_RS10065 2050504..2050800 - 297 WP_000539688.1 DUF2951 domain-containing protein -
PCM89_RS10070 2050858..2051145 - 288 WP_001040261.1 hypothetical protein -
PCM89_RS10075 2051192..2051344 - 153 WP_001153681.1 hypothetical protein -
PCM89_RS10080 2051334..2055119 - 3786 WP_000582168.1 phage tail spike protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / hlb / groEL 2045699..2102393 56694


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T267466 WP_011447039.1 NZ_CP115887:c2050354-2050178 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT267466 NZ_CP115887:2050055-2050110 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References