Detailed information of TA system TA267461

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1562020..1562599
• Replicon: chromosome
• Accession: NZ_CP115887
• Organism: Staphylococcus aureus strain C308

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: PCM89_RS07415
• Protein ID: WP_001025401.1
• Coordinates: 1562354..1562599 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1562020..1562385 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PCM89_RS07375 (1558766)	1558766..1559320	-	555	WP_000647288.1	DUF2815 family protein	-
PCM89_RS07380 (1559346)	1559346..1560512	-	1167	WP_000762534.1	DUF2800 domain-containing protein	-
PCM89_RS07385 (1560509)	1560509..1560871	-	363	WP_000985986.1	hypothetical protein	-
PCM89_RS07390 (1560886)	1560886..1561209	-	324	WP_000175000.1	hypothetical protein	-
PCM89_RS07395 (1561288)	1561288..1561449	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
PCM89_RS07400 (1561462)	1561462..1561725	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
PCM89_RS07405 (1561750)	1561750..1561965	-	216	WP_001097552.1	hypothetical protein	-
PCM89_RS07410 (1562020)	1562020..1562385	+	366	WP_001128433.1	hypothetical protein	Antitoxin
PCM89_RS07415 (1562354)	1562354..1562599	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
PCM89_RS07420 (1562666)	1562666..1563046	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
PCM89_RS07425 (1563033)	1563033..1563230	-	198	WP_001148860.1	hypothetical protein	-
PCM89_RS07430 (1563300)	1563300..1563512	+	213	WP_000362644.1	hypothetical protein	-
PCM89_RS07435 (1563553)	1563553..1563702	-	150	WP_000771849.1	hypothetical protein	-
PCM89_RS07440 (1563717)	1563717..1564160	-	444	WP_000435357.1	hypothetical protein	-
PCM89_RS07445 (1564208)	1564208..1564420	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
PCM89_RS07450 (1564572)	1564572..1565303	+	732	WP_000511090.1	XRE family transcriptional regulator	-
PCM89_RS07455 (1565374)	1565374..1565556	+	183	WP_000705240.1	hypothetical protein	-
PCM89_RS07460 (1565593)	1565593..1565739	+	147	WP_001795334.1	hypothetical protein	-
PCM89_RS07465 (1565736)	1565736..1566350	-	615	WP_000191464.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1520890..1580451	59561

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T267461 WP_001025401.1 NZ_CP115887:c1562599-1562354 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT267461 NZ_CP115887:1562020-1562385 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin