Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2881922..2882582 Replicon chromosome
Accession NZ_CP115874
Organism Enterobacter hormaechei subsp. steigerwaltii strain WYTS.MG41

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PBS85_RS13650 Protein ID WP_265188005.1
Coordinates 2882229..2882582 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0Q4Z7
Locus tag PBS85_RS13645 Protein ID WP_017383313.1
Coordinates 2881922..2882224 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PBS85_RS13630 (PBS85_13630) 2878096..2879421 + 1326 WP_047063111.1 SidA/IucD/PvdA family monooxygenase -
PBS85_RS13635 (PBS85_13635) 2879448..2881637 + 2190 WP_032654151.1 TonB-dependent siderophore receptor -
PBS85_RS13645 (PBS85_13645) 2881922..2882224 - 303 WP_017383313.1 XRE family transcriptional regulator Antitoxin
PBS85_RS13650 (PBS85_13650) 2882229..2882582 - 354 WP_265188005.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PBS85_RS13655 (PBS85_13655) 2882773..2883723 - 951 WP_077580305.1 HTH-type transcriptional regulator Cbl -
PBS85_RS13660 (PBS85_13660) 2883820..2884737 - 918 WP_003859531.1 nitrogen assimilation transcriptional regulator NAC -
PBS85_RS13670 (PBS85_13670) 2885269..2886201 - 933 WP_015572412.1 L,D-transpeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13523.34 Da        Isoelectric Point: 9.9538

>T267451 WP_265188005.1 NZ_CP115874:c2882582-2882229 [Enterobacter hormaechei subsp. steigerwaltii]
VWAVKTTDRFDDWFTSLNDSERASVLAALLVLRERGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREYTRWLNTLKERN

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11028.85 Da        Isoelectric Point: 6.4727

>AT267451 WP_017383313.1 NZ_CP115874:c2882224-2881922 [Enterobacter hormaechei subsp. steigerwaltii]
MGRTLEQLIADEKPEVVASAQAMATDILLNIHLAELREKVQKTQVDMARALGIKQPTVAVMEKAGRDIKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0Q4Z7

References