Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2566142..2566665 Replicon chromosome
Accession NC_017351
Organism Staphylococcus aureus subsp. aureus 11819-97

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag MS7_RS13270 Protein ID WP_000074045.1
Coordinates 2566142..2566408 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag MS7_RS13275 Protein ID WP_000587619.1
Coordinates 2566408..2566665 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS7_RS13250 2561448..2562635 - 1188 WP_000026189.1 MFS transporter -
MS7_RS13255 2563031..2563807 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
MS7_RS13260 2563800..2564462 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
MS7_RS13265 2564710..2565786 - 1077 WP_001076673.1 M42 family metallopeptidase -
MS7_RS13270 2566142..2566408 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
MS7_RS13275 2566408..2566665 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MS7_RS13280 2566771..2566965 - 195 WP_031864503.1 hypothetical protein -
MS7_RS13285 2567024..2567479 + 456 WP_000732090.1 YehR family lipoprotein -
MS7_RS13290 2567647..2569224 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
MS7_RS13295 2569419..2570168 + 750 WP_000072440.1 hypothetical protein -
MS7_RS13300 2570399..2571592 - 1194 WP_000675402.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T26742 WP_000074045.1 NC_017351:c2566408-2566142 [Staphylococcus aureus subsp. aureus 11819-97]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T26742 NC_017351:c2566408-2566142 [Staphylococcus aureus subsp. aureus 11819-97]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT26742 WP_000587619.1 NC_017351:c2566665-2566408 [Staphylococcus aureus subsp. aureus 11819-97]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT26742 NC_017351:c2566665-2566408 [Staphylococcus aureus subsp. aureus 11819-97]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References