Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3881276..3881873 Replicon chromosome
Accession NZ_CP115831
Organism Klebsiella pneumoniae strain L4-FAA5

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag PGO70_RS18665 Protein ID WP_004142563.1
Coordinates 3881556..3881873 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag PGO70_RS18660 Protein ID WP_004142561.1
Coordinates 3881276..3881563 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGO70_RS18630 (3877356) 3877356..3877604 + 249 WP_032445695.1 DUF1158 domain-containing protein -
PGO70_RS18635 (3877622) 3877622..3877963 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
PGO70_RS18640 (3877994) 3877994..3879109 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
PGO70_RS18645 (3879289) 3879289..3879870 + 582 Protein_3658 TetR/AcrR family transcriptional regulator -
PGO70_RS18650 (3879870) 3879870..3880238 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
PGO70_RS18655 (3880358) 3880358..3881011 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
PGO70_RS18660 (3881276) 3881276..3881563 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
PGO70_RS18665 (3881556) 3881556..3881873 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PGO70_RS18670 (3882058) 3882058..3883101 - 1044 WP_016946853.1 DUF2157 domain-containing protein -
PGO70_RS18675 (3883767) 3883767..3884633 - 867 WP_004191455.1 helix-turn-helix transcriptional regulator -
PGO70_RS18680 (3884742) 3884742..3886169 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T267406 WP_004142563.1 NZ_CP115831:c3881873-3881556 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT267406 WP_004142561.1 NZ_CP115831:c3881563-3881276 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References