Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 698936..699711 Replicon chromosome
Accession NZ_CP115831
Organism Klebsiella pneumoniae strain L4-FAA5

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag PGO70_RS03495 Protein ID WP_032445441.1
Coordinates 699226..699711 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag PGO70_RS03490 Protein ID WP_004150912.1
Coordinates 698936..699229 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGO70_RS03470 (694144) 694144..694746 - 603 WP_020802400.1 short chain dehydrogenase -
PGO70_RS03475 (694844) 694844..695755 + 912 WP_004181308.1 LysR family transcriptional regulator -
PGO70_RS03480 (695756) 695756..696904 - 1149 WP_016947441.1 PLP-dependent aspartate aminotransferase family protein -
PGO70_RS03485 (696915) 696915..698291 - 1377 WP_072158501.1 cystathionine beta-synthase -
PGO70_RS03490 (698936) 698936..699229 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
PGO70_RS03495 (699226) 699226..699711 + 486 WP_032445441.1 GNAT family N-acetyltransferase Toxin
PGO70_RS03500 (700415) 700415..701008 + 594 WP_032445442.1 hypothetical protein -
PGO70_RS03505 (701105) 701105..701321 + 217 Protein_688 transposase -
PGO70_RS03515 (701999) 701999..702712 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 701105..701257 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17580.59 Da        Isoelectric Point: 8.1558

>T267399 WP_032445441.1 NZ_CP115831:699226-699711 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGIGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT267399 WP_004150912.1 NZ_CP115831:698936-699229 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References