Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 341616..342262 Replicon chromosome
Accession NZ_CP115831
Organism Klebsiella pneumoniae strain L4-FAA5

Toxin (Protein)


Gene name higB Uniprot ID A0A231WWF9
Locus tag PGO70_RS01610 Protein ID WP_004174016.1
Coordinates 341616..341963 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PGO70_RS01615 Protein ID WP_223367845.1
Coordinates 342017..342262 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGO70_RS01600 (337542) 337542..338975 + 1434 WP_032445350.1 glycogen synthase GlgA -
PGO70_RS01605 (338993) 338993..341440 + 2448 WP_002920561.1 glycogen phosphorylase -
PGO70_RS01610 (341616) 341616..341963 + 348 WP_004174016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PGO70_RS01615 (342017) 342017..342262 + 246 WP_223367845.1 helix-turn-helix transcriptional regulator Antitoxin
PGO70_RS01620 (342325) 342325..343833 - 1509 WP_019704656.1 glycerol-3-phosphate dehydrogenase -
PGO70_RS01625 (344038) 344038..344367 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
PGO70_RS01630 (344418) 344418..345248 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
PGO70_RS01635 (345298) 345298..346056 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-66)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13518.55 Da        Isoelectric Point: 6.2327

>T267398 WP_004174016.1 NZ_CP115831:341616-341963 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8717.13 Da        Isoelectric Point: 8.6165

>AT267398 WP_223367845.1 NZ_CP115831:342017-342262 [Klebsiella pneumoniae]
IAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKSYIAALGGELSINVTLPTGKKVSFN
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A231WWF9

Antitoxin

Source ID Structure

References