Detailed information of TA system TA026739

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2509337..2509854
• Replicon: chromosome
• Accession: NC_017351
• Organism: Staphylococcus aureus subsp. aureus 11819-97

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YC79
• Locus tag: MS7_RS12965
• Protein ID: WP_000113262.1
• Coordinates: 2509337..2509603 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: MS7_RS12970
• Protein ID: WP_000584499.1
• Coordinates: 2509603..2509854 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MS7_RS12940	2504766..2505302	-	537	WP_000169317.1	GNAT family N-acetyltransferase	-
MS7_RS12945	2505535..2506359	-	825	WP_000572040.1	formate/nitrite transporter family protein	-
MS7_RS12950	2506576..2506758	-	183	WP_000230294.1	hypothetical protein	-
MS7_RS12955	2506842..2507309	-	468	WP_000153346.1	SRPBCC domain-containing protein	-
MS7_RS12960	2507495..2509042	-	1548	WP_000727756.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
MS7_RS15505	2509231..2509302	-	72	Protein_2435	hypothetical protein	-
MS7_RS12965	2509337..2509603	-	267	WP_000113262.1	Txe/YoeB family addiction module toxin	Toxin
MS7_RS12970	2509603..2509854	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MS7_RS12975	2510019..2510120	-	102	Protein_2438	hypothetical protein	-
MS7_RS12980	2510127..2510726	-	600	WP_000162810.1	DsbA family protein	-
MS7_RS12985	2510745..2511107	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
MS7_RS12990	2511362..2512612	+	1251	WP_001012218.1	FemA/FemB family glycyltransferase FmhA	-
MS7_RS12995	2512709..2513440	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
MS7_RS13000	2513437..2514156	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.95 Da
• Isoelectric Point: 9.9143

>T26739 WP_000113262.1 NC_017351:c2509603-2509337 [Staphylococcus aureus subsp. aureus 11819-97]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T26739 NC_017351:c2509603-2509337 [Staphylococcus aureus subsp. aureus 11819-97]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT26739 WP_000584499.1 NC_017351:c2509854-2509603 [Staphylococcus aureus subsp. aureus 11819-97]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT26739 NC_017351:c2509854-2509603 [Staphylococcus aureus subsp. aureus 11819-97]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Toxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7CUA
• PDB: 6L8E

Antitoxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7BWF
• PDB: 6L8E
• AlphaFold DB: T1YB60