Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 23068..23651 Replicon plasmid p3
Accession NZ_CP115771
Organism Paracoccus sediminicola strain SCSIO 76264

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PAF18_RS17120 Protein ID WP_271118326.1
Coordinates 23370..23651 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag PAF18_RS17115 Protein ID WP_271118325.1
Coordinates 23068..23358 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAF18_RS17090 (PAF18_17090) 18215..18385 + 171 WP_271118321.1 cbb3-type cytochrome c oxidase subunit 3 -
PAF18_RS17095 (PAF18_17095) 18376..19254 + 879 WP_271118322.1 cytochrome-c oxidase, cbb3-type subunit III -
PAF18_RS17100 (PAF18_17100) 19415..20296 + 882 WP_271118323.1 DUF2189 domain-containing protein -
PAF18_RS17105 (PAF18_17105) 20373..21056 - 684 WP_271118324.1 recombinase family protein -
PAF18_RS17110 (PAF18_17110) 21370..22566 - 1197 WP_271115968.1 IS256 family transposase -
PAF18_RS17115 (PAF18_17115) 23068..23358 - 291 WP_271118325.1 HigA family addiction module antitoxin Antitoxin
PAF18_RS17120 (PAF18_17120) 23370..23651 - 282 WP_271118326.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PAF18_RS17125 (PAF18_17125) 23808..24434 - 627 WP_271118327.1 hypothetical protein -
PAF18_RS17130 (PAF18_17130) 24518..24922 - 405 WP_271118328.1 hypothetical protein -
PAF18_RS17135 (PAF18_17135) 24915..25181 - 267 WP_271118329.1 ribbon-helix-helix protein, CopG family -
PAF18_RS17140 (PAF18_17140) 25174..25788 - 615 WP_271118330.1 ParA family protein -
PAF18_RS17145 (PAF18_17145) 26356..27552 + 1197 WP_271115968.1 IS256 family transposase -
PAF18_RS17150 (PAF18_17150) 27704..28327 - 624 WP_271118331.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..29546 29546
- inside IScluster/Tn - - 21370..27552 6182


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10484.08 Da        Isoelectric Point: 10.1503

>T267375 WP_271118326.1 NZ_CP115771:c23651-23370 [Paracoccus sediminicola]
MIQSTKGKLIQDILANKAGKGFPAGIMKVARRKLTMLDAASKLEDLRVPPANRLEALQGDRKGQHSIRVNDQWRFCFVWT
ESGPADVEFTDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10413.13 Da        Isoelectric Point: 5.6713

>AT267375 WP_271118325.1 NZ_CP115771:c23358-23068 [Paracoccus sediminicola]
MGLMTDPCHPGEILKHEFLEPLGVSAIGLAKVIGVPRTRVERLVKEQTAVTPDTALRLSKALGTTPEFWINMQANFDMAS
ARKTVDVSDIEPLVAA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References