Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 735676..736451 Replicon chromosome
Accession NZ_CP115714
Organism Klebsiella pneumoniae strain KPN0421

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag PF051_RS03660 Protein ID WP_060568463.1
Coordinates 735966..736451 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag PF051_RS03655 Protein ID WP_004150912.1
Coordinates 735676..735969 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF051_RS03635 (730884) 730884..731486 - 603 WP_004174410.1 short chain dehydrogenase -
PF051_RS03640 (731584) 731584..732495 + 912 WP_023342207.1 LysR family transcriptional regulator -
PF051_RS03645 (732496) 732496..733644 - 1149 WP_016947441.1 PLP-dependent aspartate aminotransferase family protein -
PF051_RS03650 (733655) 733655..735031 - 1377 WP_004174417.1 pyridoxal-phosphate dependent enzyme -
PF051_RS03655 (735676) 735676..735969 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
PF051_RS03660 (735966) 735966..736451 + 486 WP_060568463.1 GNAT family N-acetyltransferase Toxin
PF051_RS03665 (737155) 737155..737748 + 594 WP_004188553.1 hypothetical protein -
PF051_RS03670 (737845) 737845..738061 + 217 Protein_720 transposase -
PF051_RS03680 (739065) 739065..739778 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 737845..737997 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17602.64 Da        Isoelectric Point: 8.1629

>T267343 WP_060568463.1 NZ_CP115714:735966-736451 [Klebsiella pneumoniae]
MILAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRHNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT267343 WP_004150912.1 NZ_CP115714:735676-735969 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References