Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2904283..2904871 Replicon chromosome
Accession NZ_CP115713
Organism Rhodopseudomonas palustris strain k7

Toxin (Protein)


Gene name graT Uniprot ID B3QH83
Locus tag OOZ54_RS13640 Protein ID WP_012495961.1
Coordinates 2904283..2904570 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OOZ54_RS13645 Protein ID WP_012495962.1
Coordinates 2904584..2904871 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOZ54_RS13615 (OOZ54_13615) 2899829..2901334 + 1506 WP_271099828.1 caspase family protein -
OOZ54_RS13620 (OOZ54_13620) 2901389..2902225 - 837 WP_271099829.1 helix-turn-helix transcriptional regulator -
OOZ54_RS13625 (OOZ54_13625) 2902324..2903229 + 906 WP_271099830.1 SDR family oxidoreductase -
OOZ54_RS13630 (OOZ54_13630) 2903263..2903451 - 189 WP_271102874.1 hypothetical protein -
OOZ54_RS13635 (OOZ54_13635) 2903671..2904141 - 471 WP_271099831.1 hypothetical protein -
OOZ54_RS13640 (OOZ54_13640) 2904283..2904570 + 288 WP_012495961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OOZ54_RS13645 (OOZ54_13645) 2904584..2904871 + 288 WP_012495962.1 HigA family addiction module antitoxin Antitoxin
OOZ54_RS13650 (OOZ54_13650) 2904884..2906935 - 2052 WP_119018300.1 DNA topoisomerase IV subunit B -
OOZ54_RS13655 (OOZ54_13655) 2907393..2907923 + 531 WP_119018301.1 DedA family protein -
OOZ54_RS13660 (OOZ54_13660) 2908009..2908998 + 990 WP_271099832.1 MBL fold metallo-hydrolase -
OOZ54_RS13665 (OOZ54_13665) 2909143..2909688 - 546 WP_271099833.1 DUF2087 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(31-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-59)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11047.69 Da        Isoelectric Point: 10.2688

>T267338 WP_012495961.1 NZ_CP115713:2904283-2904570 [Rhodopseudomonas palustris]
MIRSWRNAATRKLWDGSRFDQFRGLDVEAAIDLLLALNAAKSLQDLSPLQSVGLHKLKGVRRNQWAMTVNDRWRICFEFR
KGDAFEVEIVDYHKG

Download         Length: 288 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10481.98 Da        Isoelectric Point: 10.6604

>AT267338 WP_012495962.1 NZ_CP115713:2904584-2904871 [Rhodopseudomonas palustris]
MAPVSHPGRLLKRELAARKLSANRLALDIGVPSGRITDILNGRRSITADTAVRLGRYFGNAPQFWLDLQSQYDIAVIERD
KGAEIDRQVRPADAA

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B3QH83

Antitoxin

Source ID Structure

References