Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1873686..1874331 Replicon chromosome
Accession NZ_CP115712
Organism Kosakonia pseudosacchari strain RX.G5M8

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PF050_RS08895 Protein ID WP_271069827.1
Coordinates 1873686..1874024 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PF050_RS08900 Protein ID WP_086873084.1
Coordinates 1874029..1874331 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF050_RS08875 (PF050_08875) 1868937..1869677 + 741 WP_271069823.1 adenosylcobinamide-GDP ribazoletransferase -
PF050_RS08880 (PF050_08880) 1869705..1870763 + 1059 WP_271069824.1 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase -
PF050_RS08885 (PF050_08885) 1870803..1871114 - 312 WP_271069825.1 helix-turn-helix domain-containing protein -
PF050_RS08890 (PF050_08890) 1871352..1873454 + 2103 WP_271069826.1 elongation factor G -
PF050_RS08895 (PF050_08895) 1873686..1874024 + 339 WP_271069827.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PF050_RS08900 (PF050_08900) 1874029..1874331 + 303 WP_086873084.1 helix-turn-helix transcriptional regulator Antitoxin
PF050_RS08905 (PF050_08905) 1874414..1875364 + 951 WP_271070127.1 L,D-transpeptidase -
PF050_RS08910 (PF050_08910) 1875508..1876533 + 1026 WP_097399495.1 LLM class flavin-dependent oxidoreductase -
PF050_RS08915 (PF050_08915) 1876703..1877179 + 477 WP_086873081.1 cold shock domain-containing protein -
PF050_RS08920 (PF050_08920) 1877425..1877964 + 540 WP_097399496.1 DUF2058 domain-containing protein -
PF050_RS08925 (PF050_08925) 1878002..1878247 + 246 WP_097399497.1 DUF2543 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1878359..1879519 1160


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(7-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13030.11 Da        Isoelectric Point: 10.3533

>T267326 WP_271069827.1 NZ_CP115712:1873686-1874024 [Kosakonia pseudosacchari]
MTQTFEKWFDALGDNDRASVLAALMVLRVKGPQLPRPYADTVKGSRYNNMKELRIQSRGEPFRVFYAFDPQRVGILLCAG
NKASNEKRFYDVMIQIADRELTRHLHKIKIKE

Download         Length: 339 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11220.03 Da        Isoelectric Point: 6.4730

>AT267326 WP_086873084.1 NZ_CP115712:1874029-1874331 [Kosakonia pseudosacchari]
MSKTLEQLIAEQKAEVVTAAQSLAQEMLLNIHLAELRERVQKTQIEMAQELGLKQPTVAVMEKQGRDIKLSTLKRYVEAT
GSKLRIDIELPDGSHYGFAL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References