Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2076048..2076347 Replicon chromosome
Accession NC_017351
Organism Staphylococcus aureus subsp. aureus 11819-97

Toxin (Protein)


Gene name txpA Uniprot ID -
Locus tag MS7_RS15150 Protein ID WP_072353918.1
Coordinates 2076171..2076347 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2076048..2076103 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS7_RS10585 2071606..2071785 + 180 WP_000669791.1 hypothetical protein -
MS7_RS10595 2072096..2072356 + 261 WP_001791826.1 hypothetical protein -
MS7_RS10600 2072409..2072759 - 351 WP_000702263.1 complement inhibitor SCIN-A -
MS7_RS10605 2073270..2073605 - 336 Protein_1987 SH3 domain-containing protein -
MS7_RS10615 2074256..2074747 - 492 WP_000920038.1 staphylokinase -
MS7_RS10620 2074938..2075693 - 756 WP_000861038.1 CHAP domain-containing protein -
MS7_RS10625 2075705..2075959 - 255 WP_000611512.1 phage holin -
MS7_RS10630 2076011..2076118 + 108 WP_001791821.1 hypothetical protein -
- 2076040..2076179 + 140 NuclAT_0 - -
- 2076040..2076179 + 140 NuclAT_0 - -
- 2076040..2076179 + 140 NuclAT_0 - -
- 2076040..2076179 + 140 NuclAT_0 - -
- 2076048..2076103 + 56 - - Antitoxin
MS7_RS15150 2076171..2076347 - 177 WP_072353918.1 putative holin-like toxin Toxin
MS7_RS10640 2076490..2076864 - 375 WP_000340977.1 hypothetical protein -
MS7_RS10645 2076920..2077207 - 288 WP_001262620.1 hypothetical protein -
MS7_RS10650 2077253..2077405 - 153 WP_001000058.1 hypothetical protein -
MS7_RS10655 2077398..2081180 - 3783 WP_000582128.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / sak / hlb / groEL 2072409..2124102 51693


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(30-58)


Sequences


Toxin        


Download         Length: 59 a.a.        Molecular weight: 6810.43 Da        Isoelectric Point: 9.9479

>T26731 WP_072353918.1 NC_017351:c2076347-2076171 [Staphylococcus aureus subsp. aureus 11819-97]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T26731 NC_017351:c2076347-2076171 [Staphylococcus aureus subsp. aureus 11819-97]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT26731 NC_017351:2076048-2076103 [Staphylococcus aureus subsp. aureus 11819-97]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References