Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1372679..1373280 Replicon chromosome
Accession NZ_CP115661
Organism Pseudomonas putida strain PD689_delTT1

Toxin (Protein)


Gene name higB Uniprot ID A0A2L1IAQ2
Locus tag PED36_RS06260 Protein ID WP_049587984.1
Coordinates 1372966..1373280 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2L1IAR7
Locus tag PED36_RS06255 Protein ID WP_049587986.1
Coordinates 1372679..1372966 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PED36_RS06235 (PED36_06235) 1367711..1368556 + 846 WP_003254799.1 DUF6502 family protein -
PED36_RS06240 (PED36_06240) 1368553..1370271 + 1719 WP_010952348.1 DUF5666 domain-containing protein -
PED36_RS06245 (PED36_06245) 1370326..1371075 + 750 WP_049587988.1 hypothetical protein -
PED36_RS06250 (PED36_06250) 1371147..1372478 - 1332 WP_004576169.1 30S ribosomal protein S12 methylthiotransferase RimO -
PED36_RS06255 (PED36_06255) 1372679..1372966 - 288 WP_049587986.1 helix-turn-helix domain-containing protein Antitoxin
PED36_RS06260 (PED36_06260) 1372966..1373280 - 315 WP_049587984.1 hypothetical protein Toxin
PED36_RS06265 (PED36_06265) 1373729..1375639 + 1911 WP_010952353.1 potassium transporter Kup -
PED36_RS06270 (PED36_06270) 1375688..1376980 - 1293 WP_010952354.1 AcvB/VirJ family lysyl-phosphatidylglycerol hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-88)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11784.61 Da        Isoelectric Point: 9.9097

>T267221 WP_049587984.1 NZ_CP115661:c1373280-1372966 [Pseudomonas putida]
MIFIETPVFTSDLKEHLDDEEYRALQAYLAEHPEAGSLLEETGGLRKIRWAAKGKGKSGGVRVIYYHVTAAHQIRMILIY
RKGIVDTLTSSQKAQLRALNKGWK

Download         Length: 315 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10841.31 Da        Isoelectric Point: 7.4063

>AT267221 WP_049587986.1 NZ_CP115661:c1372966-1372679 [Pseudomonas putida]
MEKHLFDRLVESMTQMDEIDRGERQPSREFHVDALQVKKIRQATGLSQAAFAKRIDVAVGTLRNWEQGRREPEGPARALL
RAIHNDPEHVLAALS

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L1IAQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1IAR7

References