Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2440806..2440990 Replicon chromosome
Accession NC_017349
Organism Staphylococcus aureus subsp. aureus LGA251

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag SARLGA251_RS12250 Protein ID WP_000482647.1
Coordinates 2440883..2440990 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2440806..2440866 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SARLGA251_RS12225 2436260..2436427 - 168 WP_031927726.1 hypothetical protein -
SARLGA251_RS12235 2436658..2438391 - 1734 WP_000486497.1 ABC transporter ATP-binding protein/permease -
SARLGA251_RS12240 2438416..2440179 - 1764 WP_001064840.1 ABC transporter ATP-binding protein/permease -
- 2440806..2440866 + 61 - - Antitoxin
SARLGA251_RS12250 2440883..2440990 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
SARLGA251_RS12255 2441124..2441510 - 387 WP_000779353.1 flippase GtxA -
SARLGA251_RS12260 2441778..2442920 + 1143 WP_001176867.1 glycerate kinase -
SARLGA251_RS12265 2442980..2443639 + 660 WP_000831298.1 membrane protein -
SARLGA251_RS12270 2443822..2445033 + 1212 WP_001191927.1 multidrug effflux MFS transporter -
SARLGA251_RS12275 2445156..2445629 - 474 WP_000456493.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T26722 WP_000482647.1 NC_017349:c2440990-2440883 [Staphylococcus aureus subsp. aureus LGA251]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T26722 NC_017349:c2440990-2440883 [Staphylococcus aureus subsp. aureus LGA251]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT26722 NC_017349:2440806-2440866 [Staphylococcus aureus subsp. aureus LGA251]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References