Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2415363..2415880 Replicon chromosome
Accession NC_017349
Organism Staphylococcus aureus subsp. aureus LGA251

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag SARLGA251_RS12100 Protein ID WP_000113260.1
Coordinates 2415363..2415629 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SARLGA251_RS12105 Protein ID WP_000584499.1
Coordinates 2415629..2415880 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SARLGA251_RS12070 2410515..2411051 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
SARLGA251_RS12080 2411573..2412397 - 825 WP_000594634.1 formate/nitrite transporter family protein -
SARLGA251_RS12085 2412600..2412782 - 183 WP_000079140.1 hypothetical protein -
SARLGA251_RS12090 2412869..2413336 - 468 WP_000153340.1 SRPBCC domain-containing protein -
SARLGA251_RS12095 2413522..2415069 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SARLGA251_RS12100 2415363..2415629 - 267 WP_000113260.1 Txe/YoeB family addiction module toxin Toxin
SARLGA251_RS12105 2415629..2415880 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SARLGA251_RS12110 2416045..2416146 - 102 Protein_2282 hypothetical protein -
SARLGA251_RS12115 2416153..2416752 - 600 WP_000162810.1 DsbA family protein -
SARLGA251_RS12120 2416771..2417133 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SARLGA251_RS12125 2417388..2418638 + 1251 WP_001012239.1 FemA/FemB family glycyltransferase FmhA -
SARLGA251_RS12130 2418735..2419466 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
SARLGA251_RS12135 2419463..2420182 - 720 WP_000479579.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.99 Da        Isoelectric Point: 10.0373

>T26721 WP_000113260.1 NC_017349:c2415629-2415363 [Staphylococcus aureus subsp. aureus LGA251]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRDGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T26721 NC_017349:c2415629-2415363 [Staphylococcus aureus subsp. aureus LGA251]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAGATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT26721 WP_000584499.1 NC_017349:c2415880-2415629 [Staphylococcus aureus subsp. aureus LGA251]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT26721 NC_017349:c2415880-2415629 [Staphylococcus aureus subsp. aureus LGA251]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References