Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 24698..25356 Replicon plasmid unnamed1
Accession NZ_CP115630
Organism Acinetobacter baumannii strain 2022CK-00337

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PF547_RS19715 Protein ID WP_000312250.1
Coordinates 24997..25356 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PF547_RS19710 Protein ID WP_001096429.1
Coordinates 24698..24997 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF547_RS19675 (PF547_19675) 20756..21013 + 258 WP_000834292.1 hypothetical protein -
PF547_RS19680 (PF547_19680) 21018..21590 + 573 WP_000429351.1 hypothetical protein -
PF547_RS19685 (PF547_19685) 21566..21745 + 180 WP_002081921.1 hypothetical protein -
PF547_RS19690 (PF547_19690) 21762..22391 + 630 WP_002081923.1 hypothetical protein -
PF547_RS19695 (PF547_19695) 22431..22940 + 510 WP_001043199.1 hypothetical protein -
PF547_RS19700 (PF547_19700) 23021..23575 + 555 WP_000790086.1 hypothetical protein -
PF547_RS19705 (PF547_19705) 23625..24161 + 537 WP_000731977.1 hypothetical protein -
PF547_RS19710 (PF547_19710) 24698..24997 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
PF547_RS19715 (PF547_19715) 24997..25356 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PF547_RS19720 (PF547_19720) 25557..26123 + 567 WP_031948745.1 hypothetical protein -
PF547_RS19725 (PF547_19725) 26172..26354 + 183 WP_000373384.1 hypothetical protein -
PF547_RS19730 (PF547_19730) 26421..27119 + 699 WP_000873188.1 hypothetical protein -
PF547_RS19735 (PF547_19735) 27257..27640 + 384 WP_000654347.1 hypothetical protein -
PF547_RS19740 (PF547_19740) 27707..28465 + 759 WP_001053130.1 hypothetical protein -
PF547_RS19745 (PF547_19745) 28517..28852 + 336 WP_000654055.1 hypothetical protein -
PF547_RS19750 (PF547_19750) 29719..30033 + 315 WP_000708713.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..71233 71233


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T267199 WP_000312250.1 NZ_CP115630:c25356-24997 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT267199 WP_001096429.1 NZ_CP115630:c24997-24698 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References