Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 26769..27427 Replicon plasmid unnamed1
Accession NZ_CP115624
Organism Acinetobacter baumannii strain 2022CK-00340

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PF449_RS19215 Protein ID WP_000312250.1
Coordinates 27068..27427 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PF449_RS19210 Protein ID WP_001096429.1
Coordinates 26769..27068 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF449_RS19175 (PF449_19175) 21935..22564 + 630 WP_000701002.1 hypothetical protein -
PF449_RS19180 (PF449_19180) 22604..23113 + 510 WP_038350457.1 hypothetical protein -
PF449_RS19185 (PF449_19185) 23195..23707 + 513 WP_000840065.1 hypothetical protein -
PF449_RS19190 (PF449_19190) 23763..24092 + 330 WP_000459117.1 hypothetical protein -
PF449_RS19195 (PF449_19195) 24129..24857 + 729 WP_001022819.1 hypothetical protein -
PF449_RS19200 (PF449_19200) 25093..25647 + 555 WP_000790082.1 hypothetical protein -
PF449_RS19205 (PF449_19205) 25697..26233 + 537 WP_000732006.1 hypothetical protein -
PF449_RS19210 (PF449_19210) 26769..27068 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
PF449_RS19215 (PF449_19215) 27068..27427 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PF449_RS19220 (PF449_19220) 27628..28194 + 567 WP_000710385.1 hypothetical protein -
PF449_RS19225 (PF449_19225) 28243..28425 + 183 WP_000373385.1 hypothetical protein -
PF449_RS19230 (PF449_19230) 28492..29190 + 699 WP_000873188.1 hypothetical protein -
PF449_RS19235 (PF449_19235) 29329..29712 + 384 WP_000654348.1 hypothetical protein -
PF449_RS19240 (PF449_19240) 29779..30537 + 759 WP_001053128.1 hypothetical protein -
PF449_RS19245 (PF449_19245) 30589..30924 + 336 WP_000653925.1 hypothetical protein -
PF449_RS19250 (PF449_19250) 31788..32102 + 315 WP_000708715.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..71598 71598


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T267193 WP_000312250.1 NZ_CP115624:c27427-27068 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT267193 WP_001096429.1 NZ_CP115624:c27068-26769 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References