Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4831786..4832388 Replicon chromosome
Accession NZ_CP115551
Organism Salmonella enterica subsp. enterica serovar Bispebjerg strain 20SAL-1342-3

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag PEE20_RS24085 Protein ID WP_001159630.1
Coordinates 4832077..4832388 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PEE20_RS24080 Protein ID WP_000362050.1
Coordinates 4831786..4832076 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PEE20_RS24065 (4829279) 4829279..4830181 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
PEE20_RS24070 (4830178) 4830178..4830813 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PEE20_RS24075 (4830810) 4830810..4831739 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PEE20_RS24080 (4831786) 4831786..4832076 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PEE20_RS24085 (4832077) 4832077..4832388 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PEE20_RS24090 (4832606) 4832606..4833535 + 930 WP_151117748.1 alpha/beta hydrolase -
PEE20_RS24095 (4833621) 4833621..4833932 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PEE20_RS24100 (4833929) 4833929..4834375 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PEE20_RS24105 (4834390) 4834390..4835331 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PEE20_RS24110 (4835376) 4835376..4835813 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PEE20_RS24115 (4835810) 4835810..4836682 - 873 WP_000921423.1 virulence factor BrkB family protein -
PEE20_RS24120 (4836676) 4836676..4837275 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T267186 WP_001159630.1 NZ_CP115551:c4832388-4832077 [Salmonella enterica subsp. enterica serovar Bispebjerg]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT267186 WP_000362050.1 NZ_CP115551:c4832076-4831786 [Salmonella enterica subsp. enterica serovar Bispebjerg]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References