267157

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1443540..1444195 Replicon chromosome
Accession NZ_CP115461
Organism Coxiella burnetii strain RMSFV

Toxin (Protein)


Gene name graT Uniprot ID Q83BL3
Locus tag PDI63_RS08050 Protein ID WP_010958264.1
Coordinates 1443857..1444195 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PDI63_RS08045 Protein ID WP_010958263.1
Coordinates 1443540..1443851 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PDI63_RS08025 1438818..1439495 - 678 WP_010958258.1 cyclin family protein -
PDI63_RS08030 1439813..1441195 - 1383 WP_010958260.1 cysteine--tRNA ligase -
PDI63_RS08035 1441186..1442583 - 1398 WP_010958261.1 glutamate--tRNA ligase -
PDI63_RS08040 1442740..1443471 + 732 WP_010958262.1 UDP-2,3-diacylglucosamine diphosphatase -
PDI63_RS08045 1443540..1443851 - 312 WP_010958263.1 HigA family addiction module antitoxin Antitoxin
PDI63_RS08050 1443857..1444195 - 339 WP_010958264.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PDI63_RS08055 1444554..1445699 + 1146 WP_010957722.1 ISAs1-like element ISCbu1 family transposase -
PDI63_RS08060 1446027..1447700 + 1674 WP_010958265.1 CBU_1493 family Dot/Icm T4SS effector -
PDI63_RS08065 1447874..1448629 - 756 WP_010958266.1 pyridoxine 5'-phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1444554..1445699 1145


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(23-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(26-72)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13409.66 Da        Isoelectric Point: 10.4588

>T267157 WP_010958264.1 NZ_CP115461:c1444195-1443857 [Coxiella burnetii]
MPLTLYIMLDVTRKTVILEVIIKSFKDKYTKYLYKGVSVSKWQAIRKQAERRLQILDSVTSLDDLRSLPSNRFESLRGNR
KGQFSIRINKQWRICFKWINNEPTEVEIVDYH

Download         Length: 339 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11458.39 Da        Isoelectric Point: 10.1699

>AT267157 WP_010958263.1 NZ_CP115461:c1443851-1443540 [Coxiella burnetii]
MKMAANRMRPIHPGEILAEELGFLDKMSANQLAKHLAIPTNRVTAILNGARSITADTALRLAKFFGTTPEFWLNLQDAYD
IKMALKKSGKKIEKEVTPYDQAA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q83BL3

Antitoxin

Source ID Structure

References