267144

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3803417..3804084 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag PAK35_RS17850 Protein ID WP_003417916.1
Coordinates 3803417..3803809 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag PAK35_RS17855 Protein ID WP_003912214.1
Coordinates 3803809..3804084 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS17830 (PAK35_17830) 3799264..3800253 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
PAK35_RS17835 (PAK35_17835) 3800253..3800642 - 390 Protein_3523 polyprenyl synthetase family protein -
PAK35_RS17840 (PAK35_17840) 3800695..3801956 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
PAK35_RS17845 (PAK35_17845) 3801998..3802663 - 666 Protein_3525 polyprenyl synthetase family protein -
PAK35_RS17850 (PAK35_17850) 3803417..3803809 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
PAK35_RS17855 (PAK35_17855) 3803809..3804084 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PAK35_RS17860 (PAK35_17860) 3804266..3805637 + 1372 Protein_3528 ISNCY family transposase -
PAK35_RS17865 (PAK35_17865) 3805827..3808004 + 2178 WP_016330440.1 PE family protein -
PAK35_RS17870 (PAK35_17870) 3808075..3808947 - 873 WP_003906098.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - - 3800695..3805637 4942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T267144 WP_003417916.1 NZ_CP115447:c3803809-3803417 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT267144 WP_003912214.1 NZ_CP115447:c3804084-3803809 [Mycobacterium tuberculosis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References