Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1404454..1405229 Replicon chromosome
Accession NZ_CP115182
Organism Diaphorobacter sp. ED-3

Toxin (Protein)


Gene name yhaV Uniprot ID A0A7T1GPJ5
Locus tag PCQ86_RS06805 Protein ID WP_011804662.1
Coordinates 1404771..1405229 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A7T1DU90
Locus tag PCQ86_RS06800 Protein ID WP_038204260.1
Coordinates 1404454..1404771 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCQ86_RS06790 1400781..1401875 + 1095 WP_009518528.1 signal peptidase II -
PCQ86_RS06795 1402272..1404155 - 1884 WP_009518527.1 MobH family relaxase -
PCQ86_RS06800 1404454..1404771 + 318 WP_038204260.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
PCQ86_RS06805 1404771..1405229 + 459 WP_011804662.1 type II toxin-antitoxin system YhaV family toxin Toxin
PCQ86_RS06810 1405256..1405633 + 378 WP_011804663.1 DUF3742 family protein -
PCQ86_RS06815 1405649..1407166 - 1518 WP_011804664.1 conjugal transfer protein TraG N-terminal domain-containing protein -
PCQ86_RS06820 1407181..1407540 - 360 WP_009518522.1 hypothetical protein -
PCQ86_RS06825 1407537..1408931 - 1395 WP_009518521.1 integrating conjugative element protein -
PCQ86_RS06830 1408941..1409888 - 948 WP_121382470.1 TIGR03756 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1382748..1424500 41752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(8-144)

Antitoxin

PrlF antitoxin

(8-101)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17681.07 Da        Isoelectric Point: 10.3103

>T267069 WP_011804662.1 NZ_CP115182:1404771-1405229 [Diaphorobacter sp. ED-3]
MQRHGWTLLFHDCVIEPLQKLQAAARRAQENDPKGFESNANVKLFRALSQLMLEVVPGDPARDEYRQGNTLGSAHRHWRR
AKIGRRFRLFFRYDSKAKVIVYAWVNDEQTLRSSGSKSDPYVVFEKMLGRGNPPDDWHALIQASKQDWSKLE

Download         Length: 459 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11129.57 Da        Isoelectric Point: 4.3682

>AT267069 WP_038204260.1 NZ_CP115182:1404454-1404771 [Diaphorobacter sp. ED-3]
MPAIHEVATLTSKGQVTLPKPIRQALGVDAGGKLAFDLRGSEVVVTRVDAEHEDPAIGAFLSLLARDIEAGRNVQGLPED
LARAMLEHAGHGVNLDEEIDGEVEL

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1GPJ5

Antitoxin

Source ID Structure
AlphaFold DB A0A7T1DU90

References