Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2630245..2630938 Replicon chromosome
Accession NZ_CP114896
Organism Escherichia coli strain CM93

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag O6117_RS12905 Protein ID WP_000415584.1
Coordinates 2630642..2630938 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag O6117_RS12900 Protein ID WP_000650107.1
Coordinates 2630245..2630640 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6117_RS12890 (2626109) 2626109..2628367 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
O6117_RS12895 (2628505) 2628505..2630112 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
O6117_RS12900 (2630245) 2630245..2630640 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
O6117_RS12905 (2630642) 2630642..2630938 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
O6117_RS12910 (2631143) 2631143..2631625 - 483 WP_000183505.1 GyrI-like domain-containing protein -
O6117_RS12915 (2631678) 2631678..2632070 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
O6117_RS12920 (2632222) 2632222..2632881 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
O6117_RS12925 (2632878) 2632878..2634227 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
O6117_RS12930 (2634273) 2634273..2634605 - 333 WP_000917684.1 DUF2645 family protein -
O6117_RS12935 (2634924) 2634924..2635505 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
O6117_RS12940 (2635536) 2635536..2635850 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T267032 WP_000415584.1 NZ_CP114896:c2630938-2630642 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT267032 WP_000650107.1 NZ_CP114896:c2630640-2630245 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References