267027

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1544872..1545374 Replicon chromosome
Accession NZ_CP114896
Organism Escherichia coli strain CM93

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag O6117_RS07760 Protein ID WP_000767829.1
Coordinates 1544872..1545126 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag O6117_RS07765 Protein ID WP_001259255.1
Coordinates 1545123..1545374 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6117_RS07730 (1539888) 1539888..1540115 - 228 WP_000234896.1 sulfurtransferase TusA -
O6117_RS07735 (1540129) 1540129..1541187 - 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
O6117_RS07740 (1541366) 1541366..1542724 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
O6117_RS07745 (1542714) 1542714..1542776 - 63 WP_010723108.1 membrane protein YoeI -
O6117_RS07750 (1542991) 1542991..1543919 - 929 Protein_1511 LysR substrate-binding domain-containing protein -
O6117_RS07755 (1543965) 1543965..1544789 - 825 WP_000754737.1 SDR family oxidoreductase -
O6117_RS07760 (1544872) 1544872..1545126 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
O6117_RS07765 (1545123) 1545123..1545374 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
O6117_RS07770 (1545657) 1545657..1545707 + 51 WP_001364200.1 his operon leader peptide -
O6117_RS07775 (1545853) 1545853..1546752 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
O6117_RS07780 (1546758) 1546758..1548062 + 1305 WP_000009594.1 histidinol dehydrogenase -
O6117_RS07785 (1548059) 1548059..1549129 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
O6117_RS07790 (1549129) 1549129..1550196 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T267027 WP_000767829.1 NZ_CP114896:c1545126-1544872 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT267027 WP_001259255.1 NZ_CP114896:c1545374-1545123 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References