Detailed information of TA system TA026702

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2068598..2068897
• Replicon: chromosome
• Accession: NC_017347
• Organism: Staphylococcus aureus subsp. aureus T0131

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: SAT0131_RS15450
• Protein ID: WP_072482930.1
• Coordinates: 2068721..2068897 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2068598..2068653 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAT0131_RS10350	2064155..2064334	+	180	WP_000669789.1	hypothetical protein	-
SAT0131_RS10360	2064645..2064905	+	261	WP_001791826.1	hypothetical protein	-
SAT0131_RS10365	2064958..2065308	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
SAT0131_RS15810	2065818..2066153	-	336	Protein_1970	SH3 domain-containing protein	-
SAT0131_RS10375	2066806..2067297	-	492	WP_000920041.1	staphylokinase	-
SAT0131_RS10380	2067488..2068243	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAT0131_RS10385	2068255..2068509	-	255	WP_000611512.1	phage holin	-
SAT0131_RS10390	2068561..2068668	+	108	Protein_1974	hypothetical protein	-
-	2068590..2068729	+	140	NuclAT_0	-	-
-	2068590..2068729	+	140	NuclAT_0	-	-
-	2068590..2068729	+	140	NuclAT_0	-	-
-	2068590..2068729	+	140	NuclAT_0	-	-
-	2068598..2068653	+	56	-	-	Antitoxin
SAT0131_RS15450	2068721..2068897	-	177	WP_072482930.1	putative holin-like toxin	Toxin
SAT0131_RS10400	2069006..2069779	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
SAT0131_RS10405	2070152..2070526	-	375	WP_000340977.1	hypothetical protein	-
SAT0131_RS10410	2070582..2070869	-	288	WP_001262621.1	hypothetical protein	-
SAT0131_RS10415	2070915..2071067	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	2064958..2136159	71201

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T26702 WP_072482930.1 NC_017347:c2068897-2068721 [Staphylococcus aureus subsp. aureus T0131]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T26702 NC_017347:c2068897-2068721 [Staphylococcus aureus subsp. aureus T0131]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT26702 NC_017347:2068598-2068653 [Staphylococcus aureus subsp. aureus T0131]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin