267008

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2729642..2730144 Replicon chromosome
Accession NZ_CP114895
Organism Escherichia coli strain CM56

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag O6106_RS13585 Protein ID WP_000767829.1
Coordinates 2729642..2729896 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag O6106_RS13590 Protein ID WP_001259255.1
Coordinates 2729893..2730144 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6106_RS13555 (2724657) 2724657..2724884 - 228 WP_000234896.1 sulfurtransferase TusA -
O6106_RS13560 (2724898) 2724898..2725956 - 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
O6106_RS13565 (2726135) 2726135..2727493 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
O6106_RS13570 (2727483) 2727483..2727545 - 63 WP_010723108.1 membrane protein YoeI -
O6106_RS13575 (2727760) 2727760..2728689 - 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
O6106_RS13580 (2728735) 2728735..2729559 - 825 WP_000754737.1 SDR family oxidoreductase -
O6106_RS13585 (2729642) 2729642..2729896 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
O6106_RS13590 (2729893) 2729893..2730144 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
O6106_RS13595 (2730427) 2730427..2730477 + 51 WP_001364200.1 his operon leader peptide -
O6106_RS13600 (2730623) 2730623..2731522 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
O6106_RS13605 (2731528) 2731528..2732832 + 1305 WP_000009594.1 histidinol dehydrogenase -
O6106_RS13610 (2732829) 2732829..2733899 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
O6106_RS13615 (2733899) 2733899..2734966 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T267008 WP_000767829.1 NZ_CP114895:c2729896-2729642 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT267008 WP_001259255.1 NZ_CP114895:c2730144-2729893 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References