Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 885986..886527 Replicon chromosome
Accession NZ_CP114895
Organism Escherichia coli strain CM56

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag O6106_RS04245 Protein ID WP_000615983.1
Coordinates 885986..886264 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag O6106_RS04250 Protein ID WP_000729703.1
Coordinates 886267..886527 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6106_RS04230 (883568) 883568..884146 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
O6106_RS04235 (884352) 884352..885119 + 768 WP_012305459.1 class II glutamine amidotransferase -
O6106_RS04240 (885090) 885090..885830 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
O6106_RS04245 (885986) 885986..886264 - 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
O6106_RS04250 (886267) 886267..886527 - 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
O6106_RS04255 (886737) 886737..887486 + 750 WP_000056849.1 C40 family peptidase -
O6106_RS04260 (887662) 887662..888159 + 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
O6106_RS04265 (888383) 888383..890095 - 1713 Protein_810 flagellar biosynthesis protein FlhA -
O6106_RS04270 (890067) 890067..890852 + 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T266993 WP_000615983.1 NZ_CP114895:c886264-885986 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT266993 WP_000729703.1 NZ_CP114895:c886527-886267 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References