266980

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2530796..2531489 Replicon chromosome
Accession NZ_CP114894
Organism Escherichia coli strain CM19

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag O6X69_RS12450 Protein ID WP_000415584.1
Coordinates 2531193..2531489 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag O6X69_RS12445 Protein ID WP_000650107.1
Coordinates 2530796..2531191 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6X69_RS12435 (2526660) 2526660..2528918 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
O6X69_RS12440 (2529056) 2529056..2530663 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
O6X69_RS12445 (2530796) 2530796..2531191 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
O6X69_RS12450 (2531193) 2531193..2531489 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
O6X69_RS12455 (2531694) 2531694..2532176 - 483 WP_000183505.1 GyrI-like domain-containing protein -
O6X69_RS12460 (2532229) 2532229..2532621 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
O6X69_RS12465 (2532773) 2532773..2533432 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
O6X69_RS12470 (2533429) 2533429..2534778 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
O6X69_RS12475 (2534824) 2534824..2535156 - 333 WP_000917684.1 DUF2645 family protein -
O6X69_RS12480 (2535475) 2535475..2536056 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
O6X69_RS12485 (2536087) 2536087..2536401 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T266980 WP_000415584.1 NZ_CP114894:c2531489-2531193 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T266980 NZ_CP114894:c2531489-2531193 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT266980 WP_000650107.1 NZ_CP114894:c2531191-2530796 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT266980 NZ_CP114894:c2531191-2530796 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References