Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1936297..1936990 Replicon chromosome
Accession NZ_CP114893
Organism Escherichia coli strain CM13

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag O6R07_RS09470 Protein ID WP_000415584.1
Coordinates 1936297..1936593 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag O6R07_RS09475 Protein ID WP_000650107.1
Coordinates 1936595..1936990 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6R07_RS09435 (1931385) 1931385..1931699 - 315 WP_000958598.1 putative quinol monooxygenase -
O6R07_RS09440 (1931730) 1931730..1932311 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
O6R07_RS09445 (1932630) 1932630..1932962 + 333 WP_000917684.1 DUF2645 family protein -
O6R07_RS09450 (1933008) 1933008..1934357 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
O6R07_RS09455 (1934354) 1934354..1935013 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
O6R07_RS09460 (1935165) 1935165..1935557 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
O6R07_RS09465 (1935610) 1935610..1936092 + 483 WP_000183505.1 GyrI-like domain-containing protein -
O6R07_RS09470 (1936297) 1936297..1936593 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
O6R07_RS09475 (1936595) 1936595..1936990 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
O6R07_RS09480 (1937123) 1937123..1938730 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
O6R07_RS09485 (1938868) 1938868..1941126 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T266950 WP_000415584.1 NZ_CP114893:1936297-1936593 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT266950 WP_000650107.1 NZ_CP114893:1936595-1936990 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References