Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4041761..4042302 Replicon chromosome
Accession NZ_CP114892
Organism Escherichia coli strain CM5

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag O6Q95_RS19730 Protein ID WP_000615983.1
Coordinates 4041761..4042039 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag O6Q95_RS19735 Protein ID WP_000729703.1
Coordinates 4042042..4042302 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6Q95_RS19715 (4039343) 4039343..4039921 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
O6Q95_RS19720 (4040127) 4040127..4040894 + 768 WP_012305459.1 class II glutamine amidotransferase -
O6Q95_RS19725 (4040865) 4040865..4041605 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
O6Q95_RS19730 (4041761) 4041761..4042039 - 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
O6Q95_RS19735 (4042042) 4042042..4042302 - 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
O6Q95_RS19740 (4042512) 4042512..4043261 + 750 WP_000056849.1 C40 family peptidase -
O6Q95_RS19745 (4043437) 4043437..4043934 + 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
O6Q95_RS19750 (4044158) 4044158..4045870 - 1713 Protein_3845 flagellar biosynthesis protein FlhA -
O6Q95_RS19755 (4045842) 4045842..4046627 + 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T266937 WP_000615983.1 NZ_CP114892:c4042039-4041761 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT266937 WP_000729703.1 NZ_CP114892:c4042302-4042042 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References