Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 188514..189207 Replicon chromosome
Accession NZ_CP114891
Organism Escherichia coli strain CM2

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag O6Q44_RS00960 Protein ID WP_000415584.1
Coordinates 188514..188810 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag O6Q44_RS00965 Protein ID WP_000650107.1
Coordinates 188812..189207 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6Q44_RS00925 (183602) 183602..183916 - 315 WP_000958598.1 putative quinol monooxygenase -
O6Q44_RS00930 (183947) 183947..184528 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
O6Q44_RS00935 (184847) 184847..185179 + 333 WP_000917684.1 DUF2645 family protein -
O6Q44_RS00940 (185225) 185225..186574 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
O6Q44_RS00945 (186571) 186571..187230 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
O6Q44_RS00950 (187382) 187382..187774 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
O6Q44_RS00955 (187827) 187827..188309 + 483 WP_000183505.1 GyrI-like domain-containing protein -
O6Q44_RS00960 (188514) 188514..188810 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
O6Q44_RS00965 (188812) 188812..189207 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
O6Q44_RS00970 (189340) 189340..190947 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
O6Q44_RS00975 (191085) 191085..193343 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T266894 WP_000415584.1 NZ_CP114891:188514-188810 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT266894 WP_000650107.1 NZ_CP114891:188812-189207 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References