Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2827337..2828567 Replicon chromosome
Accession NZ_CP114882
Organism Flavobacterium lacustre strain IMCC36792

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag O6P34_RS12255 Protein ID WP_269684797.1
Coordinates 2827337..2828260 (-) Length 308 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag O6P34_RS12260 Protein ID WP_269684798.1
Coordinates 2828253..2828567 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6P34_RS12245 2822451..2824442 - 1992 WP_269684795.1 hypothetical protein -
O6P34_RS12250 2824446..2827187 - 2742 WP_269684796.1 class I SAM-dependent DNA methyltransferase -
O6P34_RS12255 2827337..2828260 - 924 WP_269684797.1 HipA domain-containing protein Toxin
O6P34_RS12260 2828253..2828567 - 315 WP_269684798.1 HipA N-terminal domain-containing protein Antitoxin
O6P34_RS12265 2828570..2828779 - 210 WP_269684799.1 helix-turn-helix domain-containing protein -
O6P34_RS12270 2828955..2829716 - 762 WP_269684800.1 hypothetical protein -
O6P34_RS12275 2829716..2830372 - 657 WP_269684801.1 hypothetical protein -
O6P34_RS12280 2830379..2830783 - 405 WP_269684802.1 hypothetical protein -
O6P34_RS12285 2830836..2831123 - 288 WP_269684803.1 helix-turn-helix domain-containing protein -
O6P34_RS12290 2831334..2832437 - 1104 WP_269684804.1 hypothetical protein -
O6P34_RS12295 2832495..2833529 - 1035 WP_269684805.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(52-276)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 308 a.a.        Molecular weight: 35337.71 Da        Isoelectric Point: 8.8601

>T266876 WP_269684797.1 NZ_CP114882:c2828260-2827337 [Flavobacterium lacustre]
MNRCPITYELCGTEKYSEKGLRMIAPKLTTLHDLPFTAAEQRQEAANRAKKLSIQGVQPKLSAVISVANQQFEIVDQFGN
YIIKPQSDIFPELPENEDVTMKMAKVYGLDVPLHGLVYSKDGSLSYFIKRFDRYSKGKKYATEDFAQLTESSRDTKYDYT
MEKLVKVIDEYCTFPAIEKADFFKRILFCFITGNEDMHLKNFSVITKAGKTTLTPVYDFLNSSISIKNPQEELALSLKGK
KSNFKSTELIDYYAKDRLGLNDKTVTTILYDMNKSLSKWTELVEVSFLSDSMKEKYLKVLDNRMKRF

Download         Length: 924 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11555.32 Da        Isoelectric Point: 4.8096

>AT266876 WP_269684798.1 NZ_CP114882:c2828567-2828253 [Flavobacterium lacustre]
MKKAIIFVHNKRAGILSENTIGGYEFAYDDNYAGEPVSLTMPLSTKIYSFAKFPSFFEGLLPEGIMLEGLLKIGKIDKND
YFAQLIATGNDLVGAVTVKEWKDE

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References