Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2451480..2452169 Replicon chromosome
Accession NZ_CP114853
Organism Klebsiella pneumoniae strain S245

Toxin (Protein)


Gene name higB Uniprot ID A0A331C6E2
Locus tag O5O52_RS12135 Protein ID WP_021469727.1
Coordinates 2451480..2451797 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6B0N7G3
Locus tag O5O52_RS12140 Protein ID WP_020804705.1
Coordinates 2451873..2452169 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O5O52_RS12105 (2447182) 2447182..2447691 + 510 WP_020802144.1 GNAT family N-acetyltransferase -
O5O52_RS12110 (2447701) 2447701..2448627 + 927 WP_032435210.1 amino acid ABC transporter permease -
O5O52_RS12115 (2448611) 2448611..2449390 + 780 WP_002906697.1 amino acid ABC transporter ATP-binding protein -
O5O52_RS12120 (2449429) 2449429..2450280 + 852 WP_072198177.1 transporter substrate-binding domain-containing protein -
O5O52_RS12125 (2450358) 2450358..2450975 + 618 WP_032425015.1 glutathione S-transferase family protein -
O5O52_RS12130 (2451046) 2451046..2451273 + 228 WP_002906690.1 tautomerase PptA -
O5O52_RS12135 (2451480) 2451480..2451797 + 318 WP_021469727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O5O52_RS12140 (2451873) 2451873..2452169 + 297 WP_020804705.1 NadS family protein Antitoxin
O5O52_RS12145 (2452248) 2452248..2452694 + 447 WP_032435212.1 hypothetical protein -
O5O52_RS12150 (2452735) 2452735..2454351 - 1617 WP_004175961.1 carbohydrate porin -
O5O52_RS12155 (2454395) 2454395..2455777 - 1383 WP_004151222.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12221.10 Da        Isoelectric Point: 10.2217

>T266863 WP_021469727.1 NZ_CP114853:2451480-2451797 [Klebsiella pneumoniae]
MLTFIELQGFSKRRQVLLQDDEFRAFQEILINDPEAGDTISGTGGFRKIRWSRPGMGKRGGVRVIYYNVTKKGRIYLALI
YPKNEQDELNQEQKKMLRQVADLIN

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11057.93 Da        Isoelectric Point: 6.7277

>AT266863 WP_020804705.1 NZ_CP114853:2451873-2452169 [Klebsiella pneumoniae]
MKDELFADLLASAEEMVRIEKGEQMLMEQHVHTFSEIDVKAIREATGLKQQDFAAAVGVSYELVKSWETKRRHPTGAARK
LLLLLQGNPLIINLLKVV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331C6E2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0N7G3

References