Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 374708..375283 Replicon chromosome
Accession NZ_CP114836
Organism Halopseudomonas sp. MFKK-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag O5O48_RS01655 Protein ID WP_088274748.1
Coordinates 374708..374986 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag O5O48_RS01660 Protein ID WP_088274746.1
Coordinates 374999..375283 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O5O48_RS01650 373129..374409 + 1281 WP_269687987.1 MgtC/SapB family protein -
O5O48_RS01655 374708..374986 + 279 WP_088274748.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O5O48_RS01660 374999..375283 + 285 WP_088274746.1 HigA family addiction module antitoxin Antitoxin
O5O48_RS01665 375419..376999 - 1581 WP_269687988.1 glutamine-hydrolyzing GMP synthase -
O5O48_RS01670 377112..378584 - 1473 WP_269687989.1 IMP dehydrogenase -
O5O48_RS01675 378763..380139 + 1377 WP_269687990.1 exodeoxyribonuclease VII large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10345.86 Da        Isoelectric Point: 9.4837

>T266855 WP_088274748.1 NZ_CP114836:374708-374986 [Halopseudomonas sp. MFKK-1]
MITGFQHKGLEAFYKTGTTRGIQAAHAAKLSRILALLDVAAGPDDLNIPSFKLHQLKGELNGYWSIRVNGNWRVTFRFIG
VDVELVNYVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10222.96 Da        Isoelectric Point: 8.7598

>AT266855 WP_088274746.1 NZ_CP114836:374999-375283 [Halopseudomonas sp. MFKK-1]
MMMNPPHPGELLREDVIAELGLSVKETAERLGMSRVALSRVLNGRAAISPDLALRLEMAGVSTARAWLAMQVNYDLAQAR
QHPQPPIKALQPVG

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References